The frequency of autistic traits in the entire group was a continuum. Among 46 participants with complete results for the Autism Diagnostic Interview-Revised (ADI-R), 13 (28%) had a diagnosis of autism according to the ADI-R, and 25 (54%) had a diagnosis of autism spectrum disorder (ASD) according to the DSM-5 criteria. We investigated 64 individuals with CHARGE syndrome (35 females mean age 10.7 years, SD 7.1 years). We evaluated their adaptive functioning level and sensory particularities and extracted several data items from medical files to assess as potential risk factors for autism and/or behavioral disorders.
#CHARGE SYNDROME AND AGGRESSIVE BEHAVIOR MANUAL#
In a large national cross-sectional study, we used specific standardized tools for diagnosing autism (Autism Diagnostic Interview-Revised and Diagnostic and Statistical Manual of Mental Disorders, 5th edition, DSM-5) and evaluating behavioral disorders (Developmental Behavior Checklist-Parents, DBC-P) to investigate a series of individuals with CHARGE syndrome, defined by Verloes's criteria. The similarity of their behavioral traits with those of people with autism raises questions.
18 University Institute of France (IUF), Paris, France.īehavioral problems are an important issue for people with CHARGE syndrome.17 Department of Child Psychiatry, Necker University Hospital, AP-HP, Paris, France.16 EA 3808, University of Poitiers, Poitiers, France.15 Department of Genetics, Necker University Hospital, APHP, Paris, France.13 Genetics Unit, University Hospital of Nancy, Nancy, France.
12 Department of Paediatrics, Necker-Enfants Malades University Hospital, AP-HP, Paris, France.11 Genetics Unit, University of Bordeaux, Bordeaux, France.10 University of Poitiers, Faculty of Medicine and Pharmacy, Poitiers, France.9 Genetics Unit, CHU de Poitiers, Poitiers, France.7 INSERM Unit 1178/1018-CESP, University of Paris Sud-Paris Saclay, UVSQ Villejuif and Paris Descartes, Sorbonne Paris Cité, Paris, France.6 Faculty of Medicine, University of Paris, Paris, France. 5 Service de Pédiatrie Générale, Hôpital Universitaire Necker, 149 rue de Sèvres, 75015, Paris, France. 3 INSERM Unit 1178/1018-CESP, University of Paris Sud-Paris Saclay, UVSQ Villejuif and Paris Descartes, Sorbonne Paris Cité, Paris, France.
2 Department of Paediatrics, Necker-Enfants Malades University Hospital, AP-HP, Paris, France. 1 Faculty of Medicine, University of Paris, Paris, France.
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